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Louisiana Biomedical Research Network

Siva Murru

Link to Pubmed Publications

University of Louisiana at Monroe


Project Title

Design, Synthesis and Evaluation of Nitrogen Heterocyclic Compounds for Anti-Cancer Activity


Mentors

George Stanley, LSU

Seetharama Jois, ULM


Funding Periods

Pilot Project (May 1, 2019 - April 30, 2020)

Startup Project (May 1, 2018 - April 30, 2019)

Abstract


Cancer is one of the most difficult ailments and it became leading causes of death around the world. Anticancer agents that target DNA are generally the most effective agents in clinical use, but they are extremely toxic. Consequently, much effort has been put into finding robust anti-cancer agents that are more selective and less toxic. Along those lines, we recently obtained some interesting preliminary results on anticancer activity of our heterocyclic compounds. Currently we are planning on synthesizing new set of nitrogen heterocycles with different substitution patterns, and evaluate them for anticancer activity. Based on the preliminary results and the rationality of pyrazole moiety with known bioactive molecules, we will design and synthesize a new library of heterocycles with unique substitution patterns and evaluate for anticancer activity using variety of biological assays. The long-term goal of this project is to find novel anticancer agents for lung cancer therapy. In addition to that, we will be developing several synthetic approaches that will ultimately provide new chemical tools for the diverse range of synthetic chemists and biomedical researchers in academia and industry.