Mary Caldorera-MooreLink to Webpage
Louisiana Tech University
Multifunctional Living Stem Cell-Laden Hydrogel Networks for Directed Tissue Regeneration
Christopher Kevil, Ph.D., Louisiana State University Health Shreveport, Department of Molecular and Cellular Physiology
Full Project (May 1, 2022 - April 30, 2025)
This is a submission of a competing LBRN full proposal that will address technological deficiencies in current chronic wound treatment through the design, development, and validation of proactive biomimetic hydrogels biomaterials that will promote tissue regeneration by: 1) neutralizing the pH in the wound environment, 2) eliminating bacterial activity, and 3) promoting cell migration and re-epithelization in the wound. To accomplish this goal, the proposed project focuses on the development of hydrogel network composed of antimicrobial, mucoadhesive, and hemostatic chitosangenipin that can ultimately be used to delivery pro-healing human adipose-derived stem cells (hASCs) into sites of injury. Along with the creation of a proactive, "living" hydrogel biomaterial, the proposed biomaterials will support quantitative assessment of material properties influence on hASC fate, re-epithelization, and immunomodulation.