Louisiana Biomedical Research Network

LBRN-Webinar-Genomic Analysis of SARS-COV-2

LBRN-Webinar-Genomic Analysis of SARS-COV-2

Genomic Analysis of SARS-COV-2: New Variants and the Vaccine Rollout

This webinar will introduce the upcoming graduate Bioinformatics for Infectious Diseases Course at LSU that covers topics, tools and resources developed for infectious disease research.

As the vaccine rollout starts around the world, new variants in the spike protein of SARS-COV-2 as well as rapid evolution of this RNA virus are raising concerns about the long-term efficacy of the vaccine. In this webinar, we will discuss the ways significant mutations in viral genomes can be identified and studied in the context of evolution, protein structural changes and how to evaluate the significance of such variants for intervention measures.

Background: A SARS-CoV-2 variant, referred to as SARS-CoV-2 VUI 202012/01 (Variant Under Investigation, year 2020, month 12, variant 01), has been identified through viral genomic sequencing in the United Kingdom (UK). It is defined by multiple spike protein mutations (deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) present. Since then, similar mutations have been confirmed in the US and other parts of the world. The emergence of such mutations indicates greater transmissibility and might have other potential impacts, including:

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Flier for all the details. LBRN Webinar - New Spike Mutations.pdf